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KMID : 1044520200830010031
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Tuberculosis and Respiratory Diseases
2020 Volume.83 No. 1 p.31 ~ p.41
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Clinical Characteristics of Chronic Cough in Korea
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An Tai-Joon
Kim Jin-Woo
Choi Eun-Young
Jang Seung-Hun
Lee Hwa-Young
Kang Hye-Seon
Koo Hyeon-Kyoung
Lee Jong-Min
Kim Sung-Kyung
Shin Jong-Wook
Park So-Young
Rhee Chin-Kook
Moon Ji-Yong
Kim Yee-Hyung
Lee Hyun
Kim Yong-Hyun
Kim Je-Hyeong
Lee Sang-Haak
Kim Deog-Kyeom
Yoo Kwang-Ha
Kim Dong-Gyu
Jung Ki-Suck
Kim Hui-Jung
Yoon Hyoung-Kyu
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Abstract
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Background: Chronic cough is defined as a cough lasting more than 8 weeks and socio-economic burden of chronic cough is enormous. The characteristics of chronic cough in Korea are not well understood. The Korean Academy of Tuberculosis and Respiratory Diseases (KATRD) published guidelines on cough management in 2014. The current study evaluated the clinical characteristics of chronic cough in Korea and the efficacy of the KATRD guidelines.
Methods: This was a multi-center, retrospective observational study conducted in Korea. The participants were over 18 years of age. They had coughs lasting more than 8 weeks. Subjects with current pulmonary diseases, smokers, ex-smokers with more than 10 pack-years or who quit within the past 1 year, pregnant women, and users of cough-inducing medications were excluded. Evaluation and management of cough followed the KATRD cough-management guidelines.
Results: Participants with chronic cough in Korea showed age in the late forties and cough duration of more than 1 year. Upper airway cough syndrome was the most common cause of cough, followed by cough-variant asthma (CVA). Gastro-esophageal reflux diseases and eosinophilic bronchitis were less frequently observed. Following the KATRD cough-management guidelines, 91.2% of the subjects improved after 4 weeks of treatment. Responders were younger, had a longer duration of cough, and an initial impression of CVA. In univariate and multivariate analyses, an initial impression of CVA was the only factor related to better treatment response.
Conclusion: The causes of chronic cough in Korea differed from those reported in other countries. The current Korean guidelines proved efficient for treating Korean patients with chronic cough.
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KEYWORD
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Cough, Cohort Studies, Epidemiology, Guideline, Diagnosis, Disease Management
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